The first study on topical finasteride was done in 1997 and showed a decrease in rate of hair loss at 6 months.
In 2009, another study compared topical finasteride to oral finasteride. This study was a double blind, randomized clinical trial. Both topical and oral led to increased hair counts, although the increase occurred 1 month earlier with oral finasteride. Another difference between the two groups was that the size of the area of hair loss decreased by the fourth month of treatment in the oral finasteride group, whereas there was no significant change in the topical group.
In 2018, Lee et al. reviewed 7 studies that looked at the use of topical finasteride for the treatment of pattern hair loss in men and women. They looked at several concentrations, including finasteride 0.005%, 0.25%, and 1%. The good news is that they all showed some efficacy with limited systemic effects. Overall, topical 0.25% finasteride solution applied once a day seemed to be the most effective. The downside is that topical finasteride did cause some scalp irritation in some participants, which could be a limiting factor for some patients. It is not clear if the irritation came from the finasteride itself or from one of the other components in the solution.
In a study by Ramos et al in 2019, oral minoxidil was investigated as an alternative therapy for female pattern hair loss. In the study, which was a 24 week, randomized, open study design, they compared 1 mg oral minoxidil to 5% topical minoxidil used for 24 weeks. The authors found that the increase in density with both treatments was very similar and there was no statistically significant difference.
Oral minoxidil was well tolerated and had very few side effects. Some of the reported adverse events included mild hypertrichosis in 27% of participants and increased mean resting heart rate.
Oral minoxidil at a dose of 1 mg daily may be an option, particularly in women who cannot tolerate topical minoxidil. However, this medication should probably be avoided in patients with pre-existing cardiac disease for the moment until it has been further evaluated.
Dr. Nakatsui does not use a multi-blade scalpel. FUT is an imprecise term and as a result, there are some gray areas. In Dr. Nakatsui’s opinion, a true FUT hair transplant requires a single blade scalpel to yield a single strip. One thing is certain–if Dr. Nakatsui were to use a multi-blade scalpel, he would definitely no longer be able to state he does Ultra-Refined follicular unit hair transplants.
Some physicians do use a multi-blade scalpel to extract multiple strips in one stroke from the donor area. If these strips are dissected into 100% follicular units, this could technically still be considered FUT. However, if the strips are also broken down into non-follicular unit hair grafts or multi-follicular unit grafts like slot grafts, minigrafts, or punch grafts, then it would no longer be considered FUT.
The main advantage to using a multi-blade scalpel is speed. With a multi-blade handle, multiple thin strips can be removed in one stroke of the scalpel, potentially saving hours of work. The disadvantage is that there is a much higher change of hair transection along one or more of the blades. The more blades on the scalpel, the higher the rate of hair follicle transection and damage.
This is a patient who came in and was concerned about the progressive thinning of his frontal scalp. He had definite miniaturization of the hair in the frontal scalp. His after photos were taken one year post surgery. Because we dense packed the area, he is even able to cut his hair really (more…)
This is an Asian man who was concerned about the progressive thinning of his frontal scalp. He had definite miniaturization of the hair in the frontal scalp, especially in the temples. In the after photos, you can see we lowered the hairline in (more…)
PRP is best thought of as a collection of growth factors. These growth factors are completely natural and there is no risk of infection or allergic reactions. This is because PRP injections are taken from your own blood. This is the main reason why the treatment is so attractive to so many people–it does not require any medication or surgery and we are simply concentrating and using the natural growth factors found in your own blood!
PRP is composed of two of your blood components: plasma and platelets. Plasma can be thought of the fluid that makes up your blood and platelets are tiny cells that contain hundreds of growth factors, including platelet-derived growth factor (PDGF).
How is the procedure done?
The first step is to collect the blood using a tiny needle. Once collected, the blood is then spun down in a centrifuge. This is then processed and after separating out all the red and white blood cells, the platelet rich plasma (PRP) is concentrated and isolated. This is the part that contains the growth factors that you need. The PRP is then put into tiny syringes that make it easier to inject into the recipient areas.
Steps Involved in PRP therapy
Are there different systems used to isolate the PRP and is there a difference?
In this video, Dr. Nakatsui discusses a few of the instruments for Follicular Unit Excision (FUE) that he uses during hair transplant surgeries. Technology is always evolving and it is always important to stay at the forefront of technique and technology in order to provide the best possible experience and results for our patients. Please visit our Youtube channel for more informative videos!
Number of Grafts: 407 Areas Treated: Right retroauricular region, right temple, and mid frontal region Number of Procedures: 1 Type of Surgery:Follicular Unit Excision (FUE)
This friendly gentleman came to see Dr. Nakatsui regarding a bout of scarring alopecia that occurred over 20 years ago. He had no complaints or issues with hair thinning, rather just 3 areas of scarring alopecia. The patient advised us that he had surgery elsewhere where the surgeon excised a portion of scar. This led to a linear scar line. When dealing with hair transplants into a scar region, we know that approximately 80% of the hairs will grow and survive whereas transplanted hairs into virgin scalp will have a success rate of approximately 96-98%. The patient was made aware of the decreased survival rate and still proceeded with the surgery. Ultimately, the end result is very natural, thick, and blends in well with his surrounding hair.
Hairs come in different angles and directions all throughout the scalp. The angle the hair will be different in the front of the scalp compared to the back of the scalp. The in the retroauricular region (behind the ear), the angle of the hair is fairly flat and facing downward. If hairs were transplanted perpendicular to the natural angle of the hair, the end result will be very unnatural. For more of Dr. Nakatsui’s before and after results, please click here.
Number of Grafts: 3,000 Areas Treated: Hairline and Frontal Region Number of Procedures: 1 Type of Surgery: Follicular Unit Transplant (FUT)
This gentleman came in with progressive hair loss throughout his scalp. Dr. Nakatsui transplanted approximately 3,000 grafts for his final result. The nice thing about this patient is that he grew out his hair demonstrating that hair transplanted hairs grow just like regular hair because it is natural hair. To view more of Dr. Nakatsui’s before and after photos, please click here.
Areas Treated: Hairline and temples and mid region.
Number of procedures: 1
Type of surgery: Strip (FUT)
This gentleman came to our centre with recession to his hairline that extended back to his mid scalp. Dr. Nakatsui transplanted approximately 3,000 grafts for the final result. Close examination of the hairline demonstrates the absolute importance to angle and the use of follicular units (the very basic units of hair) when performing a hair transplant. The wonderful thing about hair transplant surgeries is that, once the transplant is complete, the hairs are generally permanent. They will act the same way as the hair from the back of your scalp; meaning they will grow at the same length and change colour at the same time generally. The best part about hair transplant surgery is that, it is your hair. To view more of Dr. Nakatsui’s before and after photos, please click here.
